Background: Breast cancer genetic (BRCA) testing for cancer susceptibility is an emerging technology in medicine.
Objective: This study assessed the knowledge and attitude of nurses regarding BRCA genetic testing in a tertiary teaching hospital in Malaysia.
Methods: A descriptive cross-sectional study was conducted among 150 nurses using a simple random sampling technique in a tertiary teaching hospital in northeast peninsular Malaysia. Data were collected using a self-administered questionnaire consisting of socio-demographic data, assessing nurses’ knowledge and attitude regarding BRCA genetic testing. Fisher exact test analysis was used to determine the association between socio-demographic characteristics with knowledge and attitude level. In addition, the overall knowledge and attitude were analysed using the sum score of each outcome based on Bloom’s cut-off point.
Results: Of the 150 nurses, 66.7% had high knowledge level about BRCA genetic testing, and 58% were positive towards genetic testing. The participants’ mean age was 28.9 years (SD = 6.70). Years of working experience (p = 0.014) significantly influenced knowledge level on BRCA genetic testing, whereas speciality working experience (p <0.001) significantly influenced BRCA genetic testing attitudes.
Conclusions: The results show that most nurses have adequate knowledge of BRCA genetic testing. However, their attitude could be termed negative. Therefore, targeted education programs on BRCA genetic testing and risk are needed to improve the knowledge and attitude of nurses and, ultimately, can educate the women and increase health-seeking behaviour among eligible women.
Copyright (c) 2021 Kien Ting Liu, Wan Rosilawati Wan Rosli, Azlina Yusuf, Soon Lean Keng
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Bellcross, C. A., Kolor, K., Goddard, K. A. B., Coates, R. J., Reyes, M., & Khoury, M. J. (2011). Awareness and utilization of BRCA1/2 testing among US primary care physicians. American Journal of Preventive Medicine, 40(1), 61-66. https://doi.org/10.1016/j.amepre.2010.09.027
Blazer, K. R., MacDonald, D. J., Culver, J. O., Huizenga, C. R., Morgan, R. J., Uman, G. C., & Weitzel, J. N. (2011). Personalized cancer genetics training for personalized medicine: improving community-based healthcare through a genetically literate workforce. Genetics in Medicine, 13(9), 832-840. https://doi.org/10.1097/GIM.0b013e31821882b7
Bloom, B. S. (1956). Taxonomy of educational objectives: the classification of educational goals; Handbook I: Cognitive domain. New York: David McKay.
Calzone, K. A., Jenkins, J., Culp, S., Bonham Jr, V. L., & Badzek, L. (2013). National nursing workforce survey of nursing attitudes, knowledge and practice in genomics. Personalized Medicine, 10(7), 719-728. https://doi.org/10.2217/pme.13.64
Calzone, K. A., Jenkins, J., Yates, J., Cusack, G., Wallen, G. R., Liewehr, D. J., . . . McBride, C. (2012). Survey of nursing integration of genomics into nursing practice. Journal of Nursing Scholarship, 44(4), 428-436. https://doi.org/10.1111/j.1547-5069.2012.01475.x
Canadian Nurses Association. (2005). Nursing and genetics: Are you ready? Nursing now, issues and trends in Canadian nursing. Canada: Canadian Nurses Association.
Chin, J. J., & Tham, H.-W. (2020). Knowledge, awareness and perception of genetic testing for hereditary disorders among Malaysians in Klang Valley. Frontiers in Genetics, 11, 512582. https://doi.org/10.3389/fgene.2020.512582
Cohn, J., Blazey, W., Tegay, D., Harper, B., Koehler, S., Laurent, B., . . . Krishnamachari, B. (2015). Physician risk assessment knowledge regarding BRCA genetics testing. Journal of Cancer Education, 30(3), 573-579. https://doi.org/10.1007/s13187-014-0724-9
Dhar, S. U., Cooper, H. P., Wang, T., Parks, B., Staggs, S. A., Hilsenbeck, S., & Plon, S. E. (2011). Significant differences among physician specialties in management recommendations of BRCA1 mutation carriers. Breast Cancer Research and Treatment, 129(1), 221-227. https://doi.org/10.1007/s10549-011-1449-7
Escher, M., & Sappino, A. P. (2000). Primary care physicians' knowledge and attitudes towards genetic testing for breast-ovarian cancer predisposition. Annals of Oncology, 11(9), 1131-1136. https://doi.org/10.1023/A:1008319114278
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007). G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175-191. https://doi.org/10.3758/BF03193146
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., . . . Bray, F. (2015). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359-E386. https://doi.org/10.1002/ijc.29210
Hu, J., Yu, L., Modanloo, S., Zhou, Y., & Yang, Y. (2018). A theoretical framework for interaction of nursing discipline with genetics and genomics. International Journal of Nursing Sciences, 5(4), 336-342. https://doi.org/10.1016/j.ijnss.2018.08.004
Huang, H., Apouey, B., & Andrews, J. (2014). Racial and ethnic disparities in awareness of cancer genetic testing among online users: Internet use, health knowledge, and socio-demographic correlates. Journal of Consumer Health on the Internet, 18(1), 15-30. https://doi.org/10.1080/15398285.2014.869165
Keating, N. L., Stoeckert, K. A., Regan, M. M., DiGianni, L., & Garber, J. E. (2008). Physicians’ experiences with BRCA1/2 testing in community settings. Journal of Clinical Oncology, 26(35), 5789. https://dx.doi.org/10.1200%2FJCO.2008.17.8053
Lopez, V. (2018). Genetic testing: Do cancer care nurses have a role? Asia-Pacific Journal of Oncology Nursing, 5(4), 391. https://dx.doi.org/10.4103%2Fapjon.apjon_23_18
Muhamad, R., Yahya, R., & Yusoff, H. M. (2012). Knowledge, attitude and practice on cardiovascular disease among women in North-Eastcoast Malaysia. International Journal of Collaborative Research on Internal Medicine & Public Health, 4(1), 85-98.
National Center for Health Statistics. (2010). National health interview survey. Retrieved from https://www.cdc.gov/nchs/nhis/nhis_2010_data_release.htm
Nelson, H. D., Pappas, M., Zakher, B., Mitchell, J. P., Okinaka-Hu, L., & Fu, R. (2014). Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: a systematic review to update the US Preventive Services Task Force recommendation. Annals of Internal Medicine, 160(4), 255-266. https://doi.org/10.7326/M13-1684
Pal, T., Cragun, D., Lewis, C., Doty, A., Rodriguez, M., Radford, C., . . . Vadaparampil, S. T. (2013). A statewide survey of practitioners to assess knowledge and clinical practices regarding hereditary breast and ovarian cancer. Genetic Testing and Molecular Biomarkers, 17(5), 367-375. https://doi.org/10.1089/gtmb.2012.0381
Peters, N., Domchek, S. M., Rose, A., Polis, R., Stopfer, J., & Armstrong, K. (2005). Knowledge, attitudes, and utilization of BRCA1/2 testing among women with early-onset breast cancer. Genetic Testing, 9(1), 48-53. https://doi.org/10.1089/gte.2005.9.48
Seven, M., Pasalak, S. I., Guvenc, G., & Kok, G. (2017). Knowledge level and educational needs of Turkish oncology nurses regarding the genetics of hereditary breast and ovarian cancer. The Journal of Continuing Education in Nursing, 48(12), 570-576. https://doi.org/10.3928/00220124-20171115-09
Smania, M. A. (2016). Use of a point-of-care tool to improve nurse practitioner BRCA knowledge. Clinical Journal of Oncology Nursing, 20(3). https://doi.org/10.1188/16.cjon.327-331
Sullivan, G. M., & Artino Jr, A. R. (2013). Analyzing and interpreting data from Likert-type scales. Journal of Graduate Medical Education, 5(4), 541-542. https://doi.org/10.4300/JGME-5-4-18
Twomey, J. (2011). Ethical, legal, psychosocial, and cultural implications of genomics for oncology nurses. Seminars in Oncology Nursing, 27(1), 54-63. https://doi.org/10.1016/j.soncn.2010.11.007
Wideroff, L., Vadaparampil, S. T., Greene, M. H., Taplin, S., Olson, L., & Freedman, A. N. (2005). Hereditary breast/ovarian and colorectal cancer genetics knowledge in a national sample of US physicians. Journal of Medical Genetics, 42(10), 749-755. http://dx.doi.org/10.1136/jmg.2004.030296
World Health Organization. (2020a). Breast cancer. Retrieved from https://www.who.int/news-room/fact-sheets/detail/breast-cancer
World Health Organization. (2020b). Breast fact sheet. Retrieved from https://gco.iarc.fr/today/data/factsheets/cancers/20-Breast-fact-sheet.pdf