NEUROCOGNITIVE IMPAIRMENT IN HIV/AIDS: A CONCEPTUAL FRAMEWORK
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Keywords

HIV
AIDS
neurocognitive impairment
review

How to Cite

Lindayani, L., Anna, A., & Ko, N.-Y. (2018). NEUROCOGNITIVE IMPAIRMENT IN HIV/AIDS: A CONCEPTUAL FRAMEWORK. Belitung Nursing Journal, 4(5), 428–436. https://doi.org/10.33546/bnj.431
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Abstract

HIV-associated with neurocognitive disorder (HAND) is a major interest issues worldwide, as results from introduction of Highly Active Antiretroviral Therapy (HAART) and increasing life expectancy. However, previous studies have been limited by lack of a guiding framework. The purpose of this review was to provide a conceptual framework to guide studies of neurocognitive impairment in patients with HIV/AIDS. A literature search was conducted of articles published from 1998 through December 2015 using the PubMed, Embase, Cochrane Library and Ebscohost databases on evaluating the problem of neurocognitive impairment in HIV. This search resulted in a total of 36 articles. Evidence has indicated that there are neurobiological changes and brain abnormalities among people living with HIV/AID, which may affect cognitive functioning. Being infected by HIV and increased age are independently factors on HAND. However, there is remaining unclear the effect of HAART, is protective factors or risk factors of HAND and its consequence on quality of life among patients with HIV/AIDS. Considering the major issues in above, patient with HIV/AIDS is vulnerable population for developing HAND that might have been resulted to under report. Future studies focus on exploring HAND is necessary especially from low income countries where the accessibility to HAART are limited.

https://doi.org/10.33546/bnj.431
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Supporting Agencies

Sekolah Tinggi Ilmu Keperawatan PPNI Jawa Barat, Bandung, Indonesia

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Copyright (c) 2018 Linlin Lindayani, Anastasia Anna, Nai-Ying Ko

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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References

Antinori, A., Arendt, G., Becker, J. T., Brew, B. J., Byrd, D. A., Cherner, M., . . . Wojna, V. E. (2007). Updated research nosology for HIV-associated neurocognitive disorders. Neurology, 69(18), 1789-1799. doi:10.1212/01.WNL.0000287431.88658.8b

Attonito, J. M., Devieux, J. G., Lerner, B. D., Hospital, M. M., & Rosenberg, R. (2014). Exploring substance use and hiv treatment factors associated with neurocognitive impairment among people living with HIV/AIDS. Front Public Health, 2, 105. doi:10.3389/fpubh.2014.00105

Brew, B. J., Pemberton, L., Cunningham, P., & Law, M. G. (1997). Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage. Journal of Infectious Disease, 175(4), 963-966.

Chan, L. G., Kandiah, N., & Chua, A. (2012). HIV-associated neurocognitive disorders (HAND) in a South Asian population - contextual application of the 2007 criteria. BMJ Open, 2(1), e000662. doi:10.1136/bmjopen-2011-000662

Chiang, M. C., Dutton, R. A., Hayashi, K. M., Lopez, O. L., Aizenstein, H. J., Toga, A. W., . . . Thompson, P. M. (2007). 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry. Neuroimage, 34(1), 44-60. doi:10.1016/j.neuroimage.2006.08.030

Cohen, R. A., Harezlak, J., Schifitto, G., Hana, G., Clark, U., Gongvatana, A., . . . Navia, B. (2010). Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era. Journal of Neurovirology, 16(1), 25-32. doi:10.3109/13550280903552420

del Palacio, M., Alvarez, S., & Munoz-Fernandez, M. A. (2012). HIV-1 infection and neurocognitive impairment in the current era. Reviews in Medical Virology, 22(1), 33-45. doi:10.1002/rmv.711

Epperson, C. N., Sammel, M. D., & Freeman, E. W. (2013). Menopause effects on verbal memory: findings from a longitudinal community cohort. The Journal of Clinical Endocrinology & Metabolism, 98(9), 3829-3838.

Ezeabogu, I., Copenhaver, M. M., & Potrepka, J. (2012). The influence of neurocognitive impairment on HIV treatment outcomes among drug-involved people living with HIV/AIDS. AIDS Care, 24(3), 386-393. doi:10.1080/09540121.2011.608794

Fazeli, P. L., Crowe, M., Ross, L. A., Wadley, V., Ball, K., & Vance, D. E. (2014). Cognitive functioning in adults aging with hiv: A cross-sectional analysis of cognitive subtypes and influential factors. Journal of Clinical Research in HIV AIDS and Prevention, 1(4), 155-169. doi:10.14302/issn.2324-7339.jcrhap-13-191

Fellows, R. P., Byrd, D. A., & Morgello, S. (2014). Effects of information processing speed on learning, memory, and executive functioning in people living with HIV/AIDS. Journal of Clinical and Experimental Neuropsychology, 36(8), 806-817. doi:10.1080/13803395.2014.943696

Fialho, R., Pereira, M., Bucur, M., Fisher, M., Whale, R., & Rusted, J. (2015). Cognitive impairment in HIV and HCV co-infected patients: A systematic review and meta-analysis. AIDS Care, 1-14. doi:10.1080/09540121.2015.1108385

Gibbie, T., Mijch, A., Ellen, S., Hoy, J., Hutchison, C., Wright, E., . . . Judd, F. (2006). Depression and neurocognitive performance in individuals with HIV/AIDS: 2-year follow-up. HIV Medicine, 7(2), 112-121. doi:10.1111/j.1468-1293.2006.00350.x

Gorman, A. A., Foley, J. M., Ettenhofer, M. L., Hinkin, C. H., & van Gorp, W. G. (2009). Functional consequences of HIV-associated neuropsychological impairment. Neuropsychology Review, 19(2), 186-203. doi:10.1007/s11065-009-9095-0

Hazleton, J. E., Berman, J. W., & Eugenin, E. A. (2010). Novel mechanisms of central nervous system damage in HIV infection. HIV AIDS (Auckland, N.Z.), 2, 39-49.

Heaton, R. K., Clifford, D. B., Franklin, D. R., Jr., Woods, S. P., Ake, C., Vaida, F., . . . Grant, I. (2010). HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology, 75(23), 2087-2096. doi:10.1212/WNL.0b013e318200d727

Heaton, R. K., Marcotte, T. D., Mindt, M. R., Sadek, J., Moore, D. J., Bentley, H., . . . Grant, I. (2004). The impact of HIV-associated neuropsychological impairment on everyday functioning. Journal of the International Neuropsychological Society, 10(3), 317-331. doi:10.1017/s1355617704102130

Hogg. (2008). Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet, 372(9635), 293-299. doi:10.1016/s0140-6736(08)61113-7

Holguin, A., Banda, M., Willen, E. J., Malama, C., Chiyenu, K. O., Mudenda, V. C., & Wood, C. (2011). HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia. AIDS Behavior, 15(8), 1895-1901. doi:10.1007/s10461-011-9988-9

Hua, X., Boyle, C. P., Harezlak, J., Tate, D. F., Yiannoutsos, C. T., Cohen, R., . . . Thompson, P. M. (2013). Disrupted cerebral metabolite levels and lower nadir CD4 + counts are linked to brain volume deficits in 210 HIV-infected patients on stable treatment. Neuroimage Clinical, 3, 132-142. doi:10.1016/j.nicl.2013.07.009

Janssen, M. A., Meulenbroek, O., Steens, S. C., Goraj, B., Bosch, M., Koopmans, P. P., & Kessels, R. P. (2015). Cognitive functioning, wellbeing and brain correlates in HIV-1 infected patients on long-term combination antiretroviral therapy. Aids, 29(16), 2139-2148. doi:10.1097/qad.0000000000000824

Letendre, S., Marquie-Beck, J., Capparelli, E., Best, B., Clifford, D., Collier, A. C., . . . Ellis, R. J. (2008). Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Archives of Neurology, 65(1), 65-70. doi:10.1001/archneurol.2007.31

Lezak, M. D. (2004). Neuropsychological assessment. Oxford: Oxford university press.

Mayston, R., Patel, V., Abas, M., Korgaonkar, P., Paranjape, R., Rodrigues, S., & Prince, M. (2013). Symptoms of common mental disorder and cognitive associations with seropositivity among a cohort of people coming for testing for HIV/AIDS in Goa, India: a cross-sectional survey. BMC Public Health, 13, 204. doi:10.1186/1471-2458-13-204

Mayston, R., Patel, V., Abas, M., Korgaonkar, P., Paranjape, R., Rodrigues, S., & Prince, M. (2015). Determinants of common mental disorder, alcohol use disorder and cognitive morbidity among people coming for HIV testing in Goa, India. Tropical Medicine and International Health, 20(3), 397-406. doi:10.1111/tmi.12435

McArthur, J. C., McClernon, D. R., Cronin, M. F., Nance-Sproson, T. E., Saah, A. J., St Clair, M., & Lanier, E. R. (1997). Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Annals of Neurology, 42(5), 689-698. doi:10.1002/ ana.410420504

Meade, C. S., Towe, S. L., Skalski, L. M., & Robertson, K. R. (2015). Independent effects of HIV infection and cocaine dependence on neurocognitive impairment in a community sample living in the southern United States. Drug and Alcohol Dependence, 149, 128-135. doi:10.1016/ j.drugalcdep.2015.01.034

Meeker, R. B., Asahchop, E., & Power, C. (2014). The brain and HAART: collaborative and combative connections. Current Opinion in HIV AIDS, 9(6), 579-584. doi:10.1097/coh.0000000000000110

Mindt, M. R., Miranda, C., Arentoft, A., Byrd, D., Monzones, J., Fuentes, A., . . . Morgello, S. (2014). Aging and HIV/AIDS: neurocognitive implications for older HIV-positive Latina/o adults. Behavioral Medicine, 40(3), 116-123. doi:10.1080/08964289. 2014.914464

Molony, E., Westfall, A. O., Perry, B. A., Tucker, R., Ritchie, C., Saag, M., . . . Merlin, J. S. (2014). Low Back Pain and Associated Imaging Findings among HIV-Infected Patients Referred to an HIV/Palliative Care Clinic. Pain Medicine, 15(3), 418-424. doi:10.1111/pme.12239

Mrus, J. M., Williams, P. L., Tsevat1, J., Cohn, S. E., & Wu, A. W. (2005). Gender differences in health-related quality of life in patients with HIV/AIDS. Quality of Life Research, 14, 479–491.

Nakku, J., Kinyanda, E., & Hoskins, S. (2013). Prevalence and factors associated with probable HIV dementia in an African population: a cross-sectional study of an HIV/AIDS clinic population. BMC Psychiatry, 13, 126. doi:10.1186/1471-244x-13-126

Nightingale, A., Ratcliffe, D., Leonidou, L., Margetts, A., Asboe, D., Gazzard, B., . . . Barber, T. J. (2014). HIV-related neurocognitive impairment screening: the patient's perspective on its utility and psychological impact. AIDS Care, 26(8), 1036-1041. doi:10.1080/09540121.2014.894619

Odiase, F. E., Ogunrin, O. A., & Ogunniyi, A. A. (2007). Memory performance in HIV/AIDS--a prospective case control study. Canadian Journal of Neurological Science, 34(2), 154-159.

Sacktor, N., Skolasky, R. L., Ernst, T., Mao, X., Selnes, O., Pomper, M. G., . . . Barker, P. B. (2005). A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. Journal of Magnetic Resonance Imaging, 21(4), 325-333. doi:10.1002/jmri.20272

Salama, C., Morris, M., Armistead, L., Koenig, L. J., Demas, P., Ferdon, C., & Bachanas, P. (2013). Depressive and conduct disorder symptoms in youth living with HIV: The independent and interactive roles of coping and neuropsychological functioning. AIDS Care, 25(2), 160-168. doi:10.1080/09540121.2012.687815

Sassoon, S. A., Rosenbloom, M. J., Fama, R., Sullivan, E. V., & Pfefferbaum, A. (2012). Selective neurocognitive deficits and poor life functioning are associated with significant depressive symptoms in alcoholism-HIV infection comorbidity. Psychiatry Research, 199(2), 102-110. doi:10.1016/j.psychres.2012.05.009

Simone, C. B., 2nd, Vapiwala, N., Hampshire, M. K., & Metz, J. M. (2012). Palliative care in the management of lung cancer: analgesic utilization and barriers to optimal pain management. Journal of Opioid Management, 8(1), 9-16.

Smith, R., Chernoff, M., Williams, P. L., Malee, K. M., Sirois, P. A., Kammerer, B., . . . Rutstein, R. (2012). Impact of HIV severity on cognitive and adaptive functioning during childhood and adolescence. Pediatr Infectious Disease Journal, 31(6), 592-598. doi:10.1097/INF.0b013e318253 844b

Thein, H., Maruff, P., Krahn, M., Kaldor, J., Koorey, D., Brew, B., & Dore, G. (2007). Cognitive function, mood and health-related quality of life in hepatitis C virus (HCV)-monoinfected and HIV/HCV-coinfected individuals commencing HCV treatment. HIV Medicine, 8(3), 192-202. doi:10.1111/j.1468-1293.2007.00452.x

Thompson, P. M., Dutton, R. A., Hayashi, K. M., Toga, A. W., Lopez, O. L., Aizenstein, H. J., & Becker, J. T. (2005). Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proceedings of the National Academy of Sciences of the United States of America, 102(43), 15647-15652. doi:10.1073/pnas. 0502548102

UNAIDS. (2015). On the fast-track to end AIDS. Geneva: UNAIDS

Vivithanaporn, P., Nelles, K., DeBlock, L., Newman, S. C., Gill, M. J., & Power, C. (2012). Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS. Journal of the Neurological Scencesi, 312(1-2), 45-51. doi:10.1016/j.jns.2011.08.025

Wade, B. S., Valcour, V. G., Wendelken-Riegelhaupt, L., Esmaeili-Firidouni, P., Joshi, S. H., Wang, Y., & Thompson, P. M. (2015). mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort. Proceedings / IEEE International Symposium on Biomedical Imaging, 2015, 971-975. doi:10.1109/isbi.2015.7164033

Woods, S. P., Moore, D. J., Weber, E., & Grant, I. (2009). Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychology Review, 19(2), 152-168. doi:10.1007/s11065-009-9102-5

Yeung, H., Krentz, H. B., Gill, M. J., & Power, C. (2006). Neuropsychiatric disorders in HIV infection: impact of diagnosis on economic costs of care. Aids, 20(16), 2005-2009. doi:10.1097/ 01.aids.0000247565.80633.d2

Yusuf, A. J., Hassan, A., Mamman, A. I., Muktar, H. M., Suleiman, A. M., & Baiyewu, O. (2014). Prevalence of HIV-Associated Neurocognitive Disorder (HAND) among patients attending a tertiary health facility in Northern Nigeria. Journal of the International Assocociation of Providers of AIDS Care. doi:10.1177/2325957414553839

Zhao, J., Li, H., Zuo, P., Li, N., Qi, S., Yuan, D., . . . Gao, Q. (2015). Altered brain functions in HIV positive patients free of HIV- associated neurocognitive disorders: A MRI study during unilateral hand movements. Radiology of Infectious Diseases, 1(2), 83-87. doi: 10.1016/j.jrid.2015.02. 009

Zhao, T., Wei, B., Long, J., Tang, X., Zhou, M., & Dang, C. (2015). Cognitive disorders in HIV-infected and AIDS patients in Guangxi, China. Journal of Neurovirology, 21(1), 32-42. doi:10.1007/s13365-014-0295-x